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Anti-RBD (CR3022)

R6,007.50R841,050.00

This antibody recognises an epitope within the corona virus receptor binding domain and binds a cross reactive epitope also present in the novel coronavirus. CR3022 works well in ELISA and western blot applications.

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SKU: Ab_300 Categories: , Tag:

Description

The CR3022 antibody we have produced is a well-known reagent whose sequence was identified by Yuan et al. from someone who recovered from the first SARS in around 2002. This antibody recognises an epitope within the corona virus receptor binding domain and binds a cross reactive epitope also present in the novel coronavirus. CR3022 works well in ELISA and western blot applications. It is available with a Human or Rabbit Fc region backbone and in 100ug or 1mg amounts.

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OVERVIEW

Product name Human Anti-SARS-CoV-2 RBD (CR3022) Antibody
Source CR3022 variable regions fused to human IgG1: Heavy chain CR3022 (GenBank: DQ168569.1) - Human Heavy chain IgG1 (UniProtKB/Swiss-Prot: P01857.1) Light chain CR3022 (GenBank: DQ168570.1) - Human kappa chain (UniProtKB/Swiss-Prot: P01834.2)
Expression host Nicotiana benthamiana plants
Tag None
Description Monoclonal antibody to COVID-19 & SARS-CoV S glycoprotein. Recombinantly expressed in Nicotiana benthamiana plants. Antibody was first described in: “Meulen et al. Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants PLoS Med. 2006 Jul; 3(7): e237 PMID:16796401”
Concentration 2 mg/ml
Volume Variable
Predicted molecular weight Heavy chain: 52 kDa. Light chain: 27 kDa

PROPERTIES

Form Liquid
Colour Clear, slightly red/brown
Preparation instructions None. Store immediately.
Storage Short term: 2 - 4°C. Long term: -20°C
Storage buffer pH 7.4. Preservative: none. 0.1M Phosphate Buffered saline (PBS)
Purification notes This product was purified by Protein A affinity chromatography.
Purity 90 - 95% as determined by SDS-PAGE (Fig. 1)
Conjugation notes None
Clonality Monoclonal
Isotype Human IgG1
Stability Up to 1 year from delivery
General notes If for any reason the product fails to give results, please contact our scientific support team for assistance.

Performance Data: Coomassie Stained Gel:

Figure 1: Coomassie stained SDS-PAGE gel showing purified CR3022. Lane 1: Molecular marker; Lane 2: Purified CR3022 antibody (10 ug loaded). Notes: Two bands of approximately 55 kDa and 30 kDa can be observed corresponding to the heavy and light chains, respectively. The protein runs at a higher molecular weight due to glycosylation.
Download our MATERIALS SAFETY DATA Sheet for more product information.

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